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The results were striking: participants receiving the highest 12 mg dose achieved mean weight loss of approximately 24.2% of baseline body weight at week 48, compared to just 2.1% with placebo - representing an astounding 22 percentage point placebo-adjusted treatment effect

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13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [2-, 11-, and 30-fold the maximum recommended human dose (MRHD) of 2 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (1-, 2-, and 7-fold MRHD) were administered to the females