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Rotate injection sites (e.g., abdomen, thighs, back of the arms) to avoid repeated trauma

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Nausea affects up to 20% of semaglutide users and is the most common reason people discontinue treatment (Alhazmi & le Roux 2026, Frontiers in Endocrinology)

In mice, CHAC1/BOTCH promotes neuronal differentiation by inhibiting NOTCH1 and both its depletion and overproduction severely disrupt neurogenesis ( CHAC1/BOTCH in zebrafish leads to severe defects in brain, heart and myotome development, resulting in embryonic lethality, highlighting its conserved and essential role (Yadav et al., 2019)