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p, p-Dichlorodiphenyltrichloroethane (p, p-DDT) and p, p-dichlorodiphenyldichloroethylene (p, p-DDE) repress prostate specific antigen levels in human prostate cancer cell lines

Inhibition of JAK or STAT1 in SGEC rescues the downregulation of SLC3A2 and GPX4 induced by IFN-, as well as IFN--induced cell death

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This disruption occurs through multiple mechanisms, including direct androgen receptor antagonism, altered steroidogenesis, and interference with androgen-regulated gene expression patterns