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Ligand-based prediction of GLP-1R agonist candidates From the different consensus combinations evaluated, only the intersection of results obtained using LY3502970/CHU-128 consensus to Biosynth database resulted in the prioritization of a single ligand-based hit (GQB47810)

Meanwhile for validation of the bio-chromatographic method in accordance to the FDA guidelines for bioanalytical methods validation, the proposed HPLC method was used to assess the LLOQ, LQC, MQC and HQC