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recently demonstrated that iron overload can lead to the proliferation of Tfh cells, the release of pro-inflammatory cytokines, and the formation of autoantibodies in lupus mice (119)

doi: 10.1007/s11010-009-0358-0

Silibinin has been proven to inhibit the upregulation of co-stimulatory molecules and major histocompatibility complex (MHC) class II molecules on lipopolysaccharide (LPS) stimulated mature DCs, while also suppressing the release of pro-inflammatory cytokines IL-12, IL-23, and TNF-, as well as CD4 + T cell proliferation and Th1/Th17 function, indicating strong immunosuppressive activity (112)

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