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Key genes involved in mitochondrial biogenesis, such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) and mitochondrial transcription factor A (TFAM), witness an uptick in their expression due to NRF2 activation [151]

After a month, she noticed increased energy levels and improved skin clarity

Excessive generation of ROS within ovarian, adipose, and hepatic tissues overpowers antioxidant defenses, leading to oxidative damage of lipids, proteins, and mitochondrial DNA ( Androgen excess exacerbates redox disequilibrium by promoting NADPH oxidase activity and mitochondrial ROS production, while simultaneously impairing follicular maturation and oocyte quality ( Figure 1 represents the involvement of redox imbalance and endocrine dysregulation in the ovary, leading to hyperandrogenism or PCOS

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