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During development and progression of atherosclerosis, Nrf2 signaling modulates many physiological and pathophysiological processes, like regulation of lipid homeostasis, CD36 gene expression regulation, foam cell formation, macrophage polarization, immunity regulation (Th2 differentiation and inhibition of pro-inflammatory gene expression through NFB down-regulation), redox regulation and inflammation, improvement of endothelial dysfunction, as well as GSH synthesis and utilization (234245)

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[DOI] [PubMed] [Google Scholar] [26].Wilhelm D, Bender K, Knebeland AP

Serious health outcomes -- yes, including death can occur with stimulant overdoses, but they were most commonly seen in those who intentionally misused the medication