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Enhanced Activity of Glutathione Reductase Glutathione reductase is the enzyme responsible for converting oxidized glutathione (GSSG) back to its reduced form (GSH) using NADPH as a cofactor

Here, we have used our quantitative thiol-metabolomics method to more accurately measure the levels of derivatised thiol species in a range of artemisinin resistant (Cam3.II R539T , Cam3.II C580Y , PL7, and MRA1240) and sensitive (Cam3.II REV , PL2 and MRA1239) isolates in both 3-6 hpi ring-and 24 hpi trophozoite-stage parasites (Fig 4)