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The Trajectory: Unlike other drugs where weight loss plateaus around the one-year mark, the data curves showed that participants on Retatrutide were still actively losing weight at week 48, suggesting even higher percentages over a longer duration

We defined psychiatric comorbidity as having alcohol and substance abuse (ICD-10: F10-F19), schizophrenia (ICD-10: F20-F29), bipolar disorders (ICD-10: F30-F31), major depression (ICD-10: F32-F33), eating disorders (ICD-10: F50), personality disorders (ICD-10: F60-F62) and psychotropics within 10 years prior to index date ( See Supplementary Table 1)

The modest reduction in triagonist-induced insulin secretion observed in Gcgr / mouse islets was mirrored by comparable reductions in insulin secretion observed with other secretagogues

CagriSema sits in a different mechanistic neighbourhood, pairing GLP-1 with amylin rather than incrementing receptor count within the incretin family