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In the existing research, the dosage was 1 g of yerba mate extract three times daily (3 g total per day)

The most commonly reported adverse effects are gastrointestinal in nature and include: Nausea (particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment when the dose is being gradually increased

Activation of gastrointestinal ileal brake response with dietary slowly digestible carbohydrates, with no observed effect on subjective appetite, in an acute randomized, double-blind, crossover trial