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Beyond just creating new enzymes, our comparative analysis uncovered previously unknown residues essential for fluorination even allowing us to rescue activity in low-performing variants

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Direct interactions between RIPK3 and enzymes, such as the pyruvate dehydrogenase complex (PDH), glutamate-ammonia ligase (GLUL), glutamate dehydrogenase 1 (GLUD1), and glycogen phosphorylase L (PYGL), can enhance energy metabolism and promote mitochondrial ROS production, thereby augmenting necroptosis in cervical adenocarcinoma and colon cancer cells [134]