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Furthermore, the greater the specific points identified where the two systems may interact, the closer the relationships [11]

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In the presence of neurological symptoms, following daily treatment, injections up to weekly or biweekly are indicated for six months before initiating monthly IM injections

The observed decrease in esr2a , though nonsignificant, is consistent with reduced esr2 protein levels and with other studies demonstrating an antagonistic effect of BPA on ER 78 due to BPA interfering with the ligand binding domain and preventing the necessary conformation for transcriptional action 7,79