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Clinical and translational studies have reported substantial changes in body weight and adipose tissue mass when the compound is evaluated in controlled trials and metabolic models, suggesting that multi-receptor agonism can alter energy balance through integrated endocrine signaling mechanisms [2][3][5]

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There are two main trials (FIGHT and LIVE trials) demonstrating that treatment with liraglutide increased the risk of adverse heart failure-associated outcomes in patients with heart failure and reduced LVEF [43-45]