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Specificity protein 1-mediated ACSL4 transcription promoted the osteoarthritis progression through suppressing the ferroptosis of chondrocytes

This enzymatic activity not only limits inflammation but also regulates lipid peroxidation and boosts the activity of other antioxidant enzymes, including superoxide dismutase (SOD) and catalase itself, further amplifying its antiviral effects [170]

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

Modulates signaling pathways such as Akt and BclXL, which are involved in cell survival, antiapoptotic responses, and tissue recovery