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doi: 10.3389/fcvm.2019.00087 4 WangHBrownPCChowECYEwartLFergusonSSFitzpatrickSet al

The induction of mitochondrial biogenesis is mediated by the activation of cAMP responsive element-binding protein (CREB) and peroxisome proliferator-activated receptor- coactivator-1 (PGC-1 ) cell signaling pathways

The most commonly reported adverse events are gastrointestinal reactions, including nausea, vomiting, diarrhea, and constipation, which typically occur during the early phase of treatment and tend to diminish or resolve with continued therapy (55, 56)

Searches for Mounjaro and Zepbound skyrocketed between 2024 and 2025, with over 1.5 million Brits now taking a weight-loss drug (a share that has nearly doubled in this period)