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It is important to note that the Fab-bound conformations may be different from the peptide agonist-bound conformations and that the ligand-bound forms may be different from the apo-form as suggested previously for GCGR 22

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This finding provides a possible explanation for the in vivo demonstration that LASSS pre-administration prevents nitration of extracellular HGF during 5-days muscle disuse (without LASSS supplementation during disuse) while the control GSSSG pre-administration does not