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These precision drug delivery systems hold significant potential for enhancing the selectivity and efficacy of CSC-targeted therapies, reducing systemic toxicity, and improving patient outcomes

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The primary interface between synaptotagmin-1 (Syt1) and the neuronal soluble N -ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is vital for the rapid synchronization of neurotransmitter release triggered by Ca 2+

Taken together, statins may accelerate ALS neuropathology by alteration of lipid profile and dysregulation of neuronal inflammatory signaling (Figure 7)