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Introduction According to the reports of the International Diabetes Federation, there were 537 million patients with diabetes worldwide in 2021, and the prevalence of diabetes was estimated at 10.5% ( With the extensive use of GLP-1 RAs, adverse drug reaction (ADR) reports are increasing gradually, which has attracted the attention of clinicians and drug administrations

It is widely studied in laboratory environments investigating metabolic signaling, endocrine regulation, and receptor-mediated pathways

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