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Thus, the literature related to the chronology of ADRD pathophysiology implicates CBF as a critical early-stage target for attenuating neurodegenerative cascades prior to symptomatic changes in brain function

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While the next SM Breeding Protocol, scheduled to be released in 2012 by the British Veterinary Association and the Kennel Club (BVA/KC), still is a work-in-progress, a preliminary draft of it (see below) would permit the breeding of cavaliers as young as 12 months old

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