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The non-genome editing technologies do not alter the host genome, which necessitates their repeated usage while keeping a check on the adverse effects, but the immune response to repeated use poses a concern for researchers and clinicians [158] (Fig

And I also think empirically, not that I like to refer to ecology or epidemiology, but when you look at ecology and epidemiology of cancer, to my knowledge the content of highly refined carbohydrate and sugar is more predictive of cancer in a society than the variety in protein content