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Given orlistat's potential to impair the absorption of certain vitamins, incorporating a daily multivitamin supplement is recommended, which should be consumed either two hours before or after taking orlistat, or at bedtime

Its structure, anchored in pharmacologic rationale, real-world feasibility, and patient safety, enables near-term implementation even as multicenter studies further define optimal hold durations, ultrasound cut-offs, and fertility outcomes

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Despite currently available therapeutics and advancements in the clinical management of heart failure and its associated complications, many challenges still remain as morbidity and mortality rates are showing no signs of decrease, (Tsao et al, 2022) highlighting unmet medical need to develop novel disease-modifying therapies for this disease