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Meta-analyses from multiple randomised controlled trials of GLP-1s in T2D populations, many with established CKD or very high cardiovascular risk, suggest roughly a 20% relative reduction in kidney outcomes, supporting a class effect

The relationship of body mass and fat distribution with incident hypertension: observations from the Dallas Heart Study

Many researchers, including our group, have focused on screening various pharmacological compounds for their ameliorative properties against the metabolic syndrome [19,20,21,22]

Limitations Despite encouraging signals for ischaemic stroke risk reduction, several evidence gaps limit inference and generalisability