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Referrals to specialists may be necessary based on the suspected cause: endocrinology for endocrine disorders or complex hypoglycemia, sleep medicine for suspected sleep apnea, hematology/oncology for suspected malignancy, or infectious disease for chronic infections

If it is cosmetic, our aesthetics team can discuss approaches without these risks

Castorina M, Ambrosini AM, Pacific L, Ramacci MT, Angelucci L (1994) Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine

If edema is persistent or worsening at 8 to 12 weeks, refer for CLT evaluation