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doi: 10.1016/j.bbabio.2010.10.022

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10.1080/14397595.2018.153755530334638 290 Tan Y, Chen Y, Wang T, et al

A1AT also has an effect on B lymphocytes, reducing their proliferation and function, as demonstrated in murine models of autoimmune diseases mediated by autoantibodies, such as rheumatoid arthritis, indicating a possible exploitation of A1AT as a therapeutic agent in autoimmune diseases (59) As for the effect on T cells, also the effect of A1AT on B lymphocytes seems to be indirect, mediated by the alterations in the extracellular milieu ( Figure 2 )