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Genetic factors may also play a role

Similar content being viewed by others Background Type 2 diabetes mellitus (T2DM), a common metabolic disorder characterized by insulin resistance and inadequate insulin secretion by pancreatic cells, has become a growing cause of morbidity and mortality worldwide

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Intuitively, small increases in ROS would be expected to activate the PI3-K/Akt pathway preferentially, while further increases would be expected to trigger p38MAPK-dependent apoptosis