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114 , e24268 (2022)

The ghrelin system is differently impaired at different ages and this impaired switch in the ghrelin system would explain the early excessive weight gain and subsequent obesity with hyperphagia observed in PWS [111, 112] However, several groups have shown that pharmacological reduction of ghrelin to normal levels in PWS, using either short or long-acting somatostatin analogue (SSA), did not improve feeding behaviour and did not reduce the appetite of children and adults with PWS nor affect the weight [55, 112]