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Anti-oxidant status in experimental hyperthyrodism: effect of vitamin E supplementation

Yale journal of biology and medicine, 2006, 79: 123-130 80

In this model, choline-deficient diet from 3 to 12 months of age disrupted liver and heart normal function, and altered neural networks associated with microtubule stability and postsynaptic membrane regulation in the hippocampus, elevated soluble and insoluble Amyloid- levels, increased Thioflavin S structures, and tau hyperphosphorylation at various pathological epitopes in the hippocampus and cortex (163)