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Specifically, mitochondrial complex I is believed to be the main component of mitochondria affected in PD as Complex I of the electron transport chain is left vulnerable to oxidative damage ( 3.4 Multiple sclerosis Multiple sclerosis (MS) is a chronic autoimmune disease that affects the CNS

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SIRT1 is also known as the longevity gene because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer