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doi: 10.1016/0003-9861(85)90056-6

In 2013, in vivo -like pathophysiology studies were carried out cultivating primary commercial human proximal tubular epithelial cells on an OoC exploiting it for a toxicity study (165)

Its uniqueness lies in its simultaneous action on three key mechanisms of metabolic regulation: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors