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This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

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[49] In large controlled clinical studies, patients were allowed to start therapy with phentermine or phentermine

Studies give extremely different results some show that high levels of IGF-1 in the elderly increase the risk of dementia, other that low levels of IGF-1 increase this risk