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Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 19 (COVID-19) has numerous risk factors leading to severe disease with high mortality rate

Any use outside approved indications would be considered off-label prescribing, which requires careful clinical justification and informed patient consent

GO analysis showed that potential targets of GSH were mainly associated with various biological processes, such as the positive regulation of cell migration, reactive oxygen species metabolic process, focal adhesion, PI3K-Akt-mTOR signaling pathway and MAPK signaling pathways, which have been shown to be involved in the pathogenesis of HF[26-30]

This analysis, updated with all GLP-1RA CVOT completed to date, supports the hypothesis that achieving HbA1c lowering with these distinct drugs might be critical for cerebrovascular events rather than MI and CV death risk reduction