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[5] In the pivotal SCALE Obesity and Prediabetes trial (Pi-Sunyer et al., NEJM 2015), adults with obesity or overweight with comorbidities who received Saxenda 3.0 mg daily alongside lifestyle intervention achieved an average weight loss of 8.0% of initial body weight at 56 weeks, compared to 2.6% in the placebo group

In Fragile X Syndrome, the FMR1 gene is silenced due to an expansion of CGG repeats, a process regulated by DNA methylation and H3K9 methylation (Liu et al., 2018

A GLP-1R agonist/GIPR antagonist peptide is theoretically possible but few full-length GIP-like antagonists were reported, 60 therefore it requires an array of attempts, at least an alanine-scan experiment of GIP with measuring of affinity