does glp 1 cause bone loss GLP-1 and GIP: Magic bullet for musculoskeletal diseases? Positive impact of GIP, GLP-1

doi: 10.1126/scitranslmed.3007218 45 OduoriOSMuraoNShimomuraKTakahashiHZhangQDouHet al

In rodents, the GLP-1 receptor expression level on thyroid C cells is high, whereas in humans, the expression of the receptor is lower

However, GIP immunoreactivity was identified in the adult rat brain using a specific monoclonal antibody against GIP (136), suggesting that while GIP is not expressed in the brain, peripheral GIP can reach the deep brain

(30) These findings suggest that semaglutide may play a role in reducing surgical-site infections and improving recovery outcomes by addressing key metabolic risk factors such as obesity, hyperglycemia, and systemic inflammation