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Acknowledgements The authors thank the research resource division (RRD) (RIKEN Center for Brain Science) and RIKEN CBS-EVIDENT Open Collaboration Center (RIKEN Center for Brain Science) for technical assistance, Yukiko Nagai (RIKEN Center for Brain Science) for secretarial work, Kenichi Nagata (Nagoya University) and members of the Laboratory for Proteolytic Neuroscience (RIKEN Center for Brain Science) for beneficial suggestions

This is being offered at specialist weight-loss clinics on the NHS in the UK.

These can include trouble with reading, seeing faces, walking, and driving

These assessments were used to describe the overall quality of the included studies but were not factored into the statistical weighting of effect estimates