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In 2021, plasma samples from the validation cohort were collected from 102 sibling pairs (102 unaffected and 102 konzo affected, 98 sex-matched, 4 pairs who are discordant for sex) in the Kahemba region of the Democratic Republic of the Congo

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These injuries refer to partial or complete damage to the tendons, muscles, and ligaments, which may or may not require surgical repair

63 By recognizing these signals, inflammasomes play a crucial role in initiating and regulating the inflammatory response in the body, particularly in response to cellular damage or microbial threats