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Continuing indefinitely without breaks accelerates receptor desensitization and increases the dose required for equivalent effect over time

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doi: 10.3389/fnut.2025.1615349 Received 21 April 2025 Accepted 04 June 2025 Published 20 June 2025 Volume 12 - 2025 Edited by Xiaolong Ji, Zhengzhou University of Light Industry, China Reviewed by Hirdayesh Anuragi, Indian Council of Agricultural Research (ICAR), India Xuefeng Guo, Tarim University, China Jing Zhang, Academy of National Food and Strategic Reserves Administration, China Updates Copyright 2025 Mohai Ud Din, Eman, Zafar, Chong, Saleh, Husien and Wang