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Increased shear stress enhances the polysaccharide intercellular adhesin (PIA) expression of the bacteria to accommodate the shear stress (Schaeffer et al., 2016)

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At a glance Program type / GLP-1-based metabolic health program with physician oversight Referral method / Unique shareable link found in the member dashboard Who qualifies / Adults with a BMI 27 or 30 with a qualifying condition Reward structure / Credit applied after referred member completes enrollment Average weight loss in comparable GLP-1 programs / 12 to 15% body weight over 68 weeks Medications used / Semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound) Physician involvement / Board-certified doctor consultation required at onboarding Support model / Ongoing behavioral coaching plus medication management What Is Calibrate and Why Does Referral Matter