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Animal toxicity studies suggest lethal doses exceed 100 mg/kg intravenously, but this doesn't mean lower human overdoses are safeindividual factors like kidney function, body weight, diabetes status, and concurrent medications dramatically alter toxicity risk

Larry Calderone, president of the Boston Police Patrolmens Association, the citys largest police union, told the Globe that it is open to negotiations with the city over how to keep health insurance costs down

These sensations often feel more obvious when appetite drops or when the body adjusts to a higher dose

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