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Lastly, we discovered an associated locus on chromosome 13 encoding the LOC107984606 gene with no immediate connection to POAG pathogenesis, as well as an association on chromosome 15 centered on a nonfunctional variant which does not encode any gene

To date there is no complete understanding of the triggering pathomechanisms of disease, and no quantitative biomarker available with sufficient sensitivity, specificity, and adoptability to provide conclusive diagnosis

Once optimal levels are achieved, the frequency might be reduced to monthly injections for maintenance

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