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Hepatocytes can adapt their enzymatic machinery in response to exposure to toxicants, a process called induction that enhances protection towards elevated levels of circulating harmful compounds [15]

Nitric oxide is a well-established vasodilator - it causes smooth muscle relaxation in the walls of blood vessels, which dilates the vessels and reduces resistance to blood flow

And this often is a form factor as you outlined or it could be dosing dynamics of a patient is not getting the outcome that theyre hoping for, are they experiencing side effects that are intolerable

doi: 10.1001/jamanetworkopen.2023.5626 52 IsraelABerkovitchMMerzonEGolan-CohenAGreenIRuppinEet al