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HIV-1 proteins, including Tat, Nef, Vpr, protease, and gp120, modulate ROS-generating systems and induce oxidative stress, thereby promoting the expression of viral genes and proinflammatory lymphokines 114,115,116

Human islets from Milan and Geneva were provided through the European Consortium for Islet Transplantation (ECIT), sponsored by JDRF (1-RSC-2014-90-I-X and 1-RSC-2014-100-I-X, respectively)