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Currently, excessive NNMT upregulation is implicated in several scenarios, including obesity, metabolic diseases, muscle cell degeneration, and even some types of cancer [2, 4]

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The innate immune cells such as macrophages, and neutrophils are a generic component of the organism response to infection or tissue damage, which includes surface barriers, the complement system, and inflammatory mediators produced by immune cells (Riera Romo et al., 2016)