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doi: 10.1016/j.phrs.2020.105157 103 MaoGXinDWang Q and LaiD

However, some individualswhether due to conditions like pernicious anemia, gastrointestinal disorders, or the effects of certain surgeriesmay have trouble absorbing enough B12 from food or oral supplements

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists