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The underlying cause is insulin deficiency, either absolute (new diagnosis of type 1 diabetes or omission of insulin in those with diagnosed disease) or relative (increased counter-regulatory hormones due to infection or other stressors without an adequate increase in insulin doses)

Exciting times, but careful evaluation of long-term safety, real-world outcomes, and patient access will be key From a neurological perspective, this overview is helpful, but what may become even more important is understanding how hormonal status shapes metabolic response