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Differentiation of ACOS patients according to their phenotype has been suggested in the GINA 2022 report

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Duart Centro de Investigacin Biomdica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), and Departamento de Biologa Celular, Biologa Funcional y Antropologa Fsica, Universidad de Valencia, Burjassot, Spain Adult stem cells are found at specific locations and their behavior and lifelong maintenance is regulated by both cell intrinsic factors and signals from the microenvironment or niche in which they reside