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Cell Death Differ (2026)

There are likely retrograde effects within the cerebellar cortex itself, but it would be interesting to test whether the responses within the thalamus and other downstream targets operate according to the topography that originates from within the cerebellum

Alongside dramatic weight reduction, participants showed impressive improvements in metabolic markers, including significant reductions in blood glucose levels, HbA1c normalization, improved lipid profiles, and substantial reductions in systemic inflammation markers like C-reactive protein (CRP)

And it has many social, commercial and environmental determinants, requiring action in many sectors not only in the clinic. These other determinants of obesity, such as a food environment rich in high sugar, fat, and salt foods, mean that the global overweight or obese population is expected to reach 60% by 2050