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This study found that in animals treated with 2-Aminobicyclo [2, 2, 1] heptane-2-carboxylic acid (BCH), a nonmetabolic analogue of leucine, the renal arteriovenous ammonia level change was greater than in the liver, indicating that hyperammonemia in GDH-HI patients is mainly induced due to increased renal ammonia production, instead of abnormalities in urea synthesis in the liver

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Rare but severe side effects can include pancreatitis, allergic reactions, kidney damage, and gallstones

Early pregnancy loss together with implantation failure occurs due to these disruptions which demonstrate why reproductive health management needs early corpus luteum assessment ( Table 5 ) (179)