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A study demonstrated that naringin inhibits the mRNA expression of inflammatory cytokines, and MMPs, including MMP-1, MMP-3, MMP-9, and MMP-13, and promotes apoptosis in RA-FLS via PI3K/Akt and MAPK/ERK signaling pathways, as shown in Figure 2 [72]

This response affects some patients and can manifest in various ways, from fatigue to physical discomfort

Of note, there was a statistically significant association after adjustment for other covariates, such as gender, age, HBV genotype, baseline HBV DNA, HBsAg, HBeAg, and ALT levels ( Table 3 )

Its role in research is limited to analytical, comparative, and observational study within structured investigational environments