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A direct cause has not been proven in a large trial, but most dermatologists recommend a baseline skin exam, regular mole photography, and stopping use if any mole changes shape, color, or size

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Folpe and Weiss labeled such areas early pleomorphic hyalinizing angiectatic tumor and considered them to represent the precursor lesion to classic PHAT, Additionally, as previously noted, small foci reminiscent of classic PHAT are often found in otherwise-typical HFLT, including small, damaged blood vessels surrounded by fibrin exudates and occasional pleomorphic cells with intranuclear pseudoinclusions (micro-PHATs)

cell migration), they work synergistically rather than redundantly