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The drugs that act on BBB integrity in the context of neurodegenerative disease warrant further investigation to understand the impact of restoring BBB integrity and protecting against breakdown

Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E & Benjamin SB (1986): Acetaminophen hepatotoxicity in alcoholics

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Studies indicate that in the absence of appropriate medical intervention, approximately 20% of patients with diabetic wounds will require lower limb amputation, with a subsequent one-year mortality rate of 13% post-diagnosis 19,20